Correction to: Circular RNA circRNA_0000094 sponges microRNA‑223‑3p and up‑regulate F‑box and WD repeat domain containing 7 to restrain T cell acute lymphoblastic leukemia progression
نویسندگان
چکیده
Circular RNAs (circRNAs) exert crucial regulatory effects in the pathogenesis of multiple tumors. This work aimed to probe into role circ_0000094 T cell acute lymphoblastic leukemia (T-ALL). In this work, quantitative real-time polymerase chain reaction (qRT-PCR) was applied quantify circ_0000094, miR-223-3p, and F-box WD repeat domain containing 7 (FBW7) mRNA expressions lymph node samples from T-ALL patients; Western blot adopted examine FBW7 protein expression cells; proliferation detected by counting kit-8 (CCK-8) experiment; apoptosis examined flow cytometry; Transwell experiments were assess migration invasion; interactions among miR-223-3p validated bioinformatics prediction, dual-luciferase reporter gene assay, RNA immunoprecipitation experiment. We reported that, markedly reduced predominantly located cytoplasm; gain-of-function loss-of-function assays verified that overexpression remarkably suppressed proliferation, migration, invasion, enhanced while knocking down malignant phenotypes rescue implied mimics partly reversed inhibitory on phenotype cells due up-regulation; proved be a molecular sponge for it could up-regulate via repressing expression. Taken together, concluded impedes progression modulating miR-223-3p/FBW7 axis.
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ژورنال
عنوان ژورنال: Human Cell
سال: 2021
ISSN: ['1749-0774', '0914-7470']
DOI: https://doi.org/10.1007/s13577-021-00574-4